N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Base Information

Chemical Name:N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide
CAS No.:1308719-25-6
Molecular Formula:C₂₈H₃₁F₂N₅O₃S
Molecular Weight:555.649
Hs Code.:

Synonyms:N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Suppliers and Price of N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

There total 4 articles about N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 859231-15-5
2-(2,4-difluorophenyl)-1-[methyl(4-aminobenzyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

: 54997-90-9
4-isopropylbenzenesulfonyl chloride

: 1308719-25-6
N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Guidance literature:: With indium; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1002/cmdc.201000530

Reference yield:

: 261959-40-4
1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol

: 1308719-25-6
N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 20 °C / 3750.38 Torr

3: indium / acetonitrile / 20 °C / Inert atmosphere

With indium; 5%-palladium/activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; acetonitrile;
DOI:10.1002/cmdc.201000530

Reference yield:

: 374557-68-3
2-(2,4-difluorophenyl)-1-[methyl(4-nitrobenzyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

: 1308719-25-6
N-[4-({[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]methylamino}methyl)phenyl]-4-isopropylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / 20 °C / 3750.38 Torr

2: indium / acetonitrile / 20 °C / Inert atmosphere

With indium; 5%-palladium/activated carbon; hydrogen; In ethanol; acetonitrile;
DOI:10.1002/cmdc.201000530