4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

Base Information

Chemical Name:4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol
CAS No.:157555-28-7
Molecular Formula:C₂₂H₃₄O₂
Molecular Weight:330.511
Hs Code.:

Synonyms:4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

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Chemical Property of 4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

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Technology Process of 4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

There total 7 articles about 4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 157555-35-6
d,l-<1α(E),4β>-2-<<1,1-dimethyl-5-<3-<2-<1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexyl>ethenyl>phenyl>pentyl>oxy>tetrahydro-2H-pyran

: 157555-28-7
4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

Guidance literature:: With acetic acid; In tetrahydrofuran; for 29h; Ambient temperature;
DOI:10.1021/jm00041a013

Reference yield:

: 78055-64-8
(3-chlorobenzyl)phosphonic acid ethyl ester

: 157555-28-7
4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaOMe / dimethylformamide / 0.25 h / 0 °C

2: 92 percent / Ni(dppp)Cl₂ / diethyl ether; tetrahydrofuran / 22 h / 31 °C

3: 79 percent / aq. acetic acid / tetrahydrofuran / 29 h / Ambient temperature

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); sodium methylate; acetic acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a013

Reference yield:

: 87787-12-0
1-methyl-t-4-(2-tetrahydropyranyloxy)-r-1-cyclohexanemethanol

: 157555-28-7
4-{(E)-2-[3-(5-Hydroxy-5-methyl-hexyl)-phenyl]-vinyl}-4-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / SO₃, pyridine, triethylamine / dimethylsulfoxide / 0.75 h / Ambient temperature

2: 100 percent / NaOMe / dimethylformamide / 0.25 h / 0 °C

3: 92 percent / Ni(dppp)Cl₂ / diethyl ether; tetrahydrofuran / 22 h / 31 °C

4: 79 percent / aq. acetic acid / tetrahydrofuran / 29 h / Ambient temperature

With pyridine; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); sulfur trioxide; sodium methylate; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a013