ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate

Base Information

• Chemical Name: ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate
• CAS No.: 138998-63-7
• Molecular Formula: C₁₄H₁₃Cl₂FN₂O₅
• Molecular Weight: 379.172
• Mol file: 138998-63-7.mol

Synonyms:ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate

Chemical Property of ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate

There total 3 articles about ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) + 2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride (104600-29-5) → ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate (138998-63-7)

Guidance literature:

With triethylamine; In benzene; at 5 - 90 ℃; for 1.5h;

DOI:10.1016/j.bmc.2017.07.036

Reference yield:

2,4-dichloro-5-fluoro-3-nitro-benzoic acid (106809-14-7) → ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate (138998-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 75 - 80 °C

2: 13.8 g / Et₃N / benzene / 20 - 90 °C

With thionyl chloride; triethylamine; In benzene;

DOI:10.3390/12061240

Reference yield:

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) + 2,4-dichloro-5-fluoro-3-nitro-benzoic acid (106809-14-7) → ethyl 2-[(2,4-dichloro-5-fluoro-3-nitrophenyl)carbonyl]-3-(dimethylamino)prop-2-enoate (138998-63-7)

Guidance literature:

2,4-dichloro-5-fluoro-3-nitro-benzoic acid; With thionyl chloride; In benzene; for 3h; Heating;

ethyl 3-(dimethylamino)acrylate; With triethylamine; In benzene; for 2h; Heating;

DOI:10.3987/COM-06-10711

upstream raw materials:

ethyl 3-(dimethylamino)acrylate

2,4-dichloro-5-fluoro-3-nitro-benzoic acid

2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride

Downstream raw materials:

ethyl 3-(N-cyclopropylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate