(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

Base Information

Chemical Name:(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine
CAS No.:1332850-55-1
Molecular Formula:C₃₅H₃₈FNO₃
Molecular Weight:539.69
Hs Code.:

Synonyms:(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

Chemical Property:

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Technology Process of (3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

There total 8 articles about (3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₇FO₉S₂

: 100-46-9
benzylamine

: 1332850-55-1
(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

Guidance literature:: at 80 ℃; for 18h;
DOI:10.1016/j.jfluchem.2011.05.031

Reference yield:

: 1309594-26-0
(5S,6S,E)-6-((S)-1,2-bis(benzyloxy)ethyl)-5-fluoroocta-2,7-dien-4-one

: 1332850-55-1
(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.33 h / 0 °C

2.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: ozone / methanol; dichloromethane / -78 °C

3.2: 3 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

5.1: 18 h / 80 °C

With dmap; sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1016/j.jfluchem.2011.05.031

Reference yield:

: 1332850-49-3
(4S,5S,6S,E)-6-((S)-1,2-bis(benzyloxy)ethyl)-5-fluoroocta-2,7-dien-4-ol

: 1332850-55-1
(3S,4S,5S)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4-fluoropiperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: ozone / methanol; dichloromethane / -78 °C

2.2: 3 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

4.1: 18 h / 80 °C

With dmap; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1016/j.jfluchem.2011.05.031