5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

Base Information

Chemical Name:5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione
CAS No.:943026-04-8
Molecular Formula:C₁₅H₁₈N₂O₄
Molecular Weight:290.319
Hs Code.:

Synonyms:5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

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Chemical Property of 5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

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Technology Process of 5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

There total 3 articles about 5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 943026-03-7
butyl 3-(2-{[4-(methyloxy)phenyl]methyl}-3,6-dioxo-1,2,3,6-tetrahydro-4-pyridazinyl)propanoate

: 943026-04-8
5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

Guidance literature:: butyl 3-(2-{[4-(methyloxy)phenyl]methyl}-3,6-dioxo-1,2,3,6-tetrahydro-4-pyridazinyl)propanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -30 - 0 ℃; for 0.5h;

With hydrogenchloride; water; pH=3;

Reference yield:

: 943026-00-4
butyl (2E)-3-[2-{[4-(methyloxy)phenyl]methyl}-6-({[4-(methyloxy)phenyl]methyl}oxy)-3-oxo-2,3-dihydro-4-pyridazinyl]-2-propenoate

: 943026-04-8
5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 2 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -30 - 0 °C

2.2: pH 3

With lithium aluminium tetrahydride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

: 943025-98-7
4-bromo-2-{[4-(methyloxy)phenyl]methyl}-6-({[4-(methyloxy)phenyl]methyl}oxy)-3(2H)-pyridazinone

: 943026-04-8
5-(3-hydroxypropyl)-1-{[4-(methyloxy)phenyl]methyl}-1,2-dihydro-3,6-pyridazinedione

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Methyldicyclohexylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 1 h / 95 °C

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; ethanol / 2 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -30 - 0 °C

3.2: pH 3

With lithium aluminium tetrahydride; N-Methyldicyclohexylamine; hydrogen; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;