Technology Process of all-trans-13,14-dihydroretinoic acid
There total 11 articles about all-trans-13,14-dihydroretinoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
13,14-dihydro-all-trans retinol;
With
NAD; NADP; 2-amino-2-hydroxymethyl-1,3-propanediol; bovine serum albumin;
retinal pigment epithelium (RPE) microsomes;
at 37 ℃;
for 1h;
pH=8.8;
Enzymatic reaction;
With
ammonium acetate;
In
water; acetonitrile;
pH=4.0;
Product distribution / selectivity;
- Guidance literature:
-
13,14-dihydroretinal;
With
NAD; NADP; ATP; 2-amino-2-hydroxymethyl-1,3-propanediol; Sucrose;
glycosylation-deficient HEK-293S cells transfected with mouse retinal dehydrogenase type 1 (HEK-RALDH1 cells);
at 37 ℃;
for 2h;
pH=8.0;
Enzymatic reaction;
With
hydroxylamine;
In
water; acetonitrile;
at 20 ℃;
for 0.5h;
pH=7.0;
With
ammonium acetate;
In
water;
pH=4.0;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetracycline-induced HEKK-mouse retinol saturase (RetSat) cells / Enzymatic reaction
2.1: 2-amino-2-hydroxymethyl-1,3-propanediol; bovine serum albumin / retinal pigment epithelium (RPE) microsomes / 1 h / 37 °C / pH 8.8 / Enzymatic reaction
2.2: pH 4.0
With
2-amino-2-hydroxymethyl-1,3-propanediol; bovine serum albumin;
tetracycline-induced HEKK-mouse retinol saturase (RetSat) cells; retinal pigment epithelium (RPE) microsomes;
