2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene
CAS No.:1221349-30-9
Molecular Formula:C₂₂H₂₀F₃N₃O
Molecular Weight:399.416
Hs Code.:

Synonyms:2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

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Chemical Property of 2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

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Technology Process of 2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

There total 6 articles about 2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1259026-16-8
2-(trichloromethyl)-5-(2-(trifluoromethyl)phenyl)-1H-benzimidazole

: 19968-85-5
1-(aminomethyl)cyclohexanol hydrochloride

: 1221349-30-9
2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 14h;
DOI:10.1021/jm101075v

Reference yield:

: 471240-43-4
2'-(trifluoromethyl)-[1,1'-biphenyl]-3,4-diamine

: 1221349-30-9
2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 14 h / 20 °C

2: sodium hydroxide / 1,4-dioxane; water / 14 h / 20 °C

With acetic acid; sodium hydroxide; In 1,4-dioxane; water;
DOI:10.1021/jm101075v

Reference yield:

: 1221349-90-1
3-nitro-2'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine

: 1221349-30-9
2-(5-(2-(trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C

2: acetic acid / 14 h / 20 °C

3: sodium hydroxide / 1,4-dioxane; water / 14 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm101075v