ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE

Base Information

• Chemical Name: ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE
• CAS No.: 61586-79-6
• Molecular Formula: C8H14 O3
• Molecular Weight: 158.19
• Hs Code.: 2918199090
• Mol file: 61586-79-6.mol

Synonyms:Cyclopentanecarboxylicacid, 2-hydroxy-, ethyl ester, (1R-cis)-; Ethyl (1R,2S)-2-hydroxycyclopentane-1-carboxylate;Ethyl (1R,2S)-2-hydroxycyclopentanecarboxylate

Chemical Property of ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: n20/D 1.458
• Boiling Point: 129-130℃ (P=42 TORR)
• PKA: 14.65±0.40(Predicted)
• Flash Point: 101 °C
• PSA: 46.53000
• Density: 1.073 g/mL at 20ºC(lit.)
• LogP: 0.71050
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(1R,2S)-Ethyl2-hydroxycyclopentanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25-25-24

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE

There total 39 articles about ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOPENTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 2-cis-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopentanecarboxylate → ethyl cis-(±)-2-hydroxycyclopentane-1-carboxylate (1883-91-6,2315-21-1,54972-10-0,61586-79-6,63599-14-4,63599-15-5,110611-67-1,110611-68-2,122331-03-7)

Guidance literature:

With sodium perborate tetrahydrate; In tetrahydrofuran; water; at 27 ℃; Inert atmosphere;

DOI:10.1039/c7ob01382e

Reference yield: 71.0%

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → ethyl cis-(±)-2-hydroxycyclopentane-1-carboxylate (1883-91-6,2315-21-1,54972-10-0,61586-79-6,63599-14-4,63599-15-5,110611-67-1,110611-68-2,122331-03-7) + ethyl trans-2-hydroxy-1-cyclopentane carboxylate (1883-91-6,2315-21-1,54972-10-0,61586-79-6,63599-14-4,63599-15-5,110611-67-1,110611-68-2,122331-03-7)

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/S0957-4166(03)00366-5

Reference yield: 71.0%

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → ethyl cis-(±)-2-hydroxycyclopentane-1-carboxylate (1883-91-6,2315-21-1,54972-10-0,61586-79-6,63599-14-4,63599-15-5,110611-67-1,110611-68-2,122331-03-7) + ethyl trans-2-hydroxy-1-cyclopentane carboxylate (1883-91-6,2315-21-1,54972-10-0,61586-79-6,63599-14-4,63599-15-5,110611-67-1,110611-68-2,122331-03-7)

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/S0957-4166(03)00366-5

upstream raw materials:

2-ethoxycarbonyl-1-cyclopentanone

Diazoethan

Ethyl 2-acetoxy-1-cyclopentene-1-carboxylate

ethyl 2-thioxo-1-cyclopentanecarboxylate

Downstream raw materials:

(+/-)-cis-2-hydroxy-cyclopentane-carboxylic acid-⁽¹⁾-hydrazide

(+/-)-trans-2-hydroxy-cyclopentane-carboxylic acid-⁽¹⁾-hydrazide

(+/-)-trans-2-(3.5-dinitro-benzoyloxy)-cyclopentane-carboxylic acid-⁽¹⁾-ethyl ester

(+/-)-cis-2-(3,5-dinitro-benzoyloxy)-cyclopentane-carboxylic acid-⁽¹⁾-ethyl ester