2-(3,5-difluorophenyl)-1H-pyrrole

Base Information

• Chemical Name: 2-(3,5-difluorophenyl)-1H-pyrrole
• CAS No.: 1229035-74-8
• Molecular Formula: C₁₀H₇F₂N
• Molecular Weight: 179.169
• Mol file: 1229035-74-8.mol

Synonyms:2-(3,5-difluorophenyl)-1H-pyrrole

Chemical Property of 2-(3,5-difluorophenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(3,5-Difluorophenyl)pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-difluorophenyl)-1H-pyrrole

There total 1 articles about 2-(3,5-difluorophenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

pyrrole (109-97-7,30604-81-0) + 3,5-difluorophenylboronic acid (156545-07-2) → 2-(3,5-difluorophenyl)-1H-pyrrole (1229035-74-8)

Guidance literature:

With iron(II) oxalate dihydrate; 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-triene; at 130 ℃; for 10h; regioselective reaction;

DOI:10.1021/ol100838m

Reference yield:

2-(3,5-difluorophenyl)-1H-pyrrole (1229035-74-8) → 2-methyl-5-(3',5'-difluorophenyl)pyrrole (1309456-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 1.17 h / 0 - 40 °C / Inert atmosphere

1.2: 0.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/ja203190t

Reference yield:

2-(3,5-difluorophenyl)-1H-pyrrole (1229035-74-8) → 5-methyl-2-(3',5'-difluorophenyl)-1-pyrroline

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1.17 h / 0 - 40 °C / Inert atmosphere

1.2: 0.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3.1: palladium(II) trifluoroacetate; 5,5’-bis(diphenylphosphino)-4,4’-bi-1,3-benzodioxole; ethanesulfonic acid; hydrogen / 2,2,2-trifluoroethanol / Inert atmosphere

With lithium aluminium tetrahydride; 5,5’-bis(diphenylphosphino)-4,4’-bi-1,3-benzodioxole; palladium(II) trifluoroacetate; ethanesulfonic acid; hydrogen; trichlorophosphate; In tetrahydrofuran; 2,2,2-trifluoroethanol;

DOI:10.1021/ja203190t

upstream raw materials:

pyrrole

3,5-difluorophenylboronic acid

Downstream raw materials:

2-methyl-5-(3',5'-difluorophenyl)pyrrole

(+)-(R)-5-methyl-2-(3',5'-difluorophenyl)-1-pyrroline