(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

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Chemical Name:(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid
CAS No.:1613724-82-5
Molecular Formula:C₅₁H₈₁N₃O₁₁
Molecular Weight:912.218
Hs Code.:

(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

Synonyms:(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

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Chemical Property of (6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

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Technology Process of (6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

There total 20 articles about (6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1613724-70-1
prop-2-en-1-yl (6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[ (benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oate

: 1613724-82-5
(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/hlca.201300255

Reference yield:

: (αR,βS,4S,5S)-β,2,2,5-tetramethyl-α-tridecyl-1,3-dioxan-4-ethanol

: 1613724-82-5
(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 2.5 h / 0 °C / Inert atmosphere

2.1: acetic acid / water / 10 h / 20 °C / Inert atmosphere

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; sodium chlorite / water; acetonitrile / 0.33 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.2: 4.15 h / 0 - 20 °C / Inert atmosphere

6.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

With morpholine; dmap; sodium chlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.201300255

Reference yield:

: 1613724-79-0
(2S,3R)-2-[(4S,5S)-2,2,5-trimethyl-1,3-dioxan-4-yl]hexadecan-3-yl (2S)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoate

: 1613724-82-5
(6S,12R)-18-[(1S)-1-(benzyloxy)ethyl]-6-[(benzyloxy)methyl]-11-hydroxy-2,2,10,12-tetramethyl-4,7,13,16-tetraoxo-15-(propan-2-yl)-9-tridecyl-3,8-dioxa-5,14,17-triazanonadecan-19-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / water / 10 h / 20 °C / Inert atmosphere

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; sodium chlorite / water; acetonitrile / 0.33 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: 4.15 h / 0 - 20 °C / Inert atmosphere

5.1: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

With morpholine; sodium chlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/hlca.201300255