N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Base Information

Chemical Name:N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide
CAS No.:259874-58-3
Molecular Formula:C₂₇H₃₃NO₂SSi
Molecular Weight:463.716
Hs Code.:

Synonyms:N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Suppliers and Price of N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Chemical Property:

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Technology Process of N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

There total 7 articles about N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 259874-56-1
N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)phthalimide

: 98-59-9
p-toluenesulfonyl chloride

: 259874-58-3
N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Guidance literature:: N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)phthalimide; With hydrazine hydrate; In ethanol; at 20 ℃; for 12h;

p-toluenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/ol991341o

Reference yield:

: 259874-44-7
5-(benzyldimethylsilyl)-1-(tetrahydropyran-2′-yloxy)pent-4-yne

: 259874-58-3
N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 65 percent / DIBALH / diethyl ether; hexane / 40 h / 20 °C

2.1: 92 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

3.1: 95 percent / diethyl ether / 0.5 h

4.1: 58 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 57 h / 20 °C

5.1: NH₂NH₂*H₂O / ethanol / 12 h / 20 °C

5.2: 60 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

With oxalyl dichloride; diisobutylaluminium hydride; hydrazine hydrate; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; 1.1: Reduction / 2.1: Oxidation / 3.1: Grignard reaction / 4.1: Substitution / 5.1: Elimination / 5.2: Tosylation;
DOI:10.1021/ol991341o

Reference yield:

: 259874-48-1
(Z)-5-benzyldimethylsilyl-4-pentenal

: 259874-58-3
N-((Z)-5-benzyldimethylsilyl-1-phenyl-4-pentenyl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / diethyl ether / 0.5 h

2.1: 58 percent / diethyl azodicarboxylate; PPh₃ / tetrahydrofuran / 57 h / 20 °C

3.1: NH₂NH₂*H₂O / ethanol / 12 h / 20 °C

3.2: 60 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; 1.1: Grignard reaction / 2.1: Substitution / 3.1: Elimination / 3.2: Tosylation;
DOI:10.1021/ol991341o