2-(4-Hydroxy-3-methoxyphenyl)propanoic acid

Base Information

Chemical Name:2-(4-Hydroxy-3-methoxyphenyl)propanoic acid
CAS No.:56355-43-2
Molecular Formula:C₁₀H₁₂O₄
Molecular Weight:196.203
Hs Code.:
DSSTox Substance ID:DTXSID801246825
Wikidata:Q104960840

Synonyms:2-(4-hydroxy-3-methoxyphenyl)propanoic acid;56355-43-2;SCHEMBL490839;CJBZBOQPGGQIOM-UHFFFAOYSA-N;DTXSID801246825;4-hydroxy-3-methoxypheny propionic acid;4-hydroxy-3-methoxyphenylpropionic acid;2-(4-hydroxy-3-methoxy-phenyl)-propionic acid;EN300-1850459;4-Hydroxy-3-methoxy-I+/--methylbenzeneacetic acid

Suppliers and Price of 2-(4-Hydroxy-3-methoxyphenyl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Hydroxy-3-methoxyphenyl)propanoic acid

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:196.07355886
Heavy Atom Count:14
Complexity:204

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)O)OC)C(=O)O

Technology Process of 2-(4-Hydroxy-3-methoxyphenyl)propanoic acid

There total 3 articles about 2-(4-Hydroxy-3-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1391847-85-0
C₂₄H₂₄O₄

: 56355-43-2
4-hydroxy-3-methoxy-phenylpropionic acid

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.06.059

Reference yield:

: 306-08-1
Homovanillic acid

: 56355-43-2
4-hydroxy-3-methoxy-phenylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 15 h / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; acetone;
DOI:10.1016/j.bmcl.2012.06.059

Reference yield:

: 65340-85-4
benzyl 2-(4-(benzyloxy)-3-methoxyphenyl)acetate

: 56355-43-2
4-hydroxy-3-methoxy-phenylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C

With palladium on activated charcoal; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.06.059