(2R,3S)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

Base Information

Chemical Name:(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide
CAS No.:107036-13-5
Molecular Formula:C₂₂H₃₁NO₂S
Molecular Weight:373.56
Hs Code.:

Synonyms:(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

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Chemical Property of (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

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Technology Process of (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

There total 5 articles about (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

: 107036-37-3
(3-{(2S,3R)-2,3-Bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pentylsulfanyl}-propyl)-dimethyl-amine

: 107036-13-5
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; methanol; for 0.5h;
DOI:10.1021/jm00388a015

Reference yield:

: 104946-98-7
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-pentanethiol

: 107036-13-5
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

Guidance literature:: Multi-step reaction with 5 steps

1: 79.4 percent / sodium methoxide / dioxane / 1 h / 45 °C

2: 60.6 percent / LiAlH₄ / tetrahydrofuran / 0.33 h

3: 93 percent / Et₃N / tetrahydrofuran / 0.33 h

4: 52.5 percent / tetrahydrofuran / 20 h / Heating

5: 68.5 percent / KF, 18-crown-6 / tetrahydrofuran; methanol / 0.5 h

With potassium fluoride; lithium aluminium tetrahydride; 18-crown-6 ether; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm00388a015

Reference yield:

: 107036-30-6
(2R*,3S*)-2,3-bis<4-(tert-butyldimethylsiloxy)phenyl>pentyl 3-hydroxypropyl sulfide

: 107036-13-5
(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentyl 3-(N,N-dimethylamino)propyl sulfide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Et₃N / tetrahydrofuran / 0.33 h

2: 52.5 percent / tetrahydrofuran / 20 h / Heating

3: 68.5 percent / KF, 18-crown-6 / tetrahydrofuran; methanol / 0.5 h

With potassium fluoride; 18-crown-6 ether; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm00388a015