(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

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Chemical Name:(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol
CAS No.:224637-00-7
Molecular Formula:C₂₈H₄₀O₇Si
Molecular Weight:516.707
Hs Code.:

Synonyms:(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

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Chemical Property of (1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

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Technology Process of (1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

There total 6 articles about (1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4S)-5-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-3,4-dihydroxy-dihydro-furan-2-one

: 224637-00-7
(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-lutidine / CH₂Cl₂ / -10 °C

2: SmI₂ / acetic acid; tetrahydrofuran

3: PhNEt₂

4: 1.) DIBAL, 2.) LiAlH₄ / 1.) CH₂Cl₂, 2.) Et₂O

5: Et₃N / DMAP

6: mCPBA/Na₂HPO₄*2H₂O

With 2,6-dimethylpyridine; disodium hydrogenphosphate; lithium aluminium tetrahydride; samarium diiodide; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; dmap; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(97)01484-6

Reference yield:

: Acetic acid (3R,4R)-4-acetoxy-2-[(R)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5-oxo-tetrahydro-furan-3-yl ester

: 224637-00-7
(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: SmI₂ / acetic acid; tetrahydrofuran

2: PhNEt₂

3: 1.) DIBAL, 2.) LiAlH₄ / 1.) CH₂Cl₂, 2.) Et₂O

4: Et₃N / DMAP

5: mCPBA/Na₂HPO₄*2H₂O

With disodium hydrogenphosphate; lithium aluminium tetrahydride; samarium diiodide; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; dmap; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0040-4039(97)01484-6

Reference yield:

: 195503-33-4
(Z)-(4R,5S)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-5-methoxymethoxy-pent-2-ene-1,4-diol

: 224637-00-7
(1R,2S)-1-[(2R,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methoxymethoxy-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / DMAP

2: mCPBA/Na₂HPO₄*2H₂O

With disodium hydrogenphosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; dmap;
DOI:10.1016/S0040-4039(97)01484-6