(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate
CAS No.:912480-01-4
Molecular Formula:C₂₅H₂₆N₂O₅
Molecular Weight:434.492
Hs Code.:

Synonyms:(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

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Chemical Property of (S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

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Technology Process of (S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

There total 4 articles about (S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 2449-05-0
dibenzyl azodicarboxylate

: 912480-01-4
(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

: 438470-79-2
(R)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 3-phenyl-propionaldehyde; dibenzyl azodicarboxylate; With L-proline; In acetonitrile; at 0 - 20 ℃; for 3h;

With sodium tetrahydroborate; In ethanol; acetonitrile; at 0 ℃; for 0.0833333h; Further stages.;
DOI:10.1021/ja0261325

Reference yield:

: C₂₅H₂₄N₂O₅

: 912480-01-4
(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

Guidance literature:: With sodium tetrahydroborate; In ethanol; dichloromethane; for 0.333333h;
DOI:10.1002/adsc.201200887 DOI:10.1002/adsc.201200887

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 2449-05-0
dibenzyl azodicarboxylate

: 912480-01-4
(S)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)-hydrazine-1,2-dicarboxylate

: 438470-79-2
(R)-dibenzyl 1-(1-hydroxy-3-phenylpropan-2-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: 3-phenyl-propionaldehyde; dibenzyl azodicarboxylate; With O-lauroyl-trans-4-hydroxy-L-proline; sodium hydrogencarbonate; sodium chloride; In water; at 20 ℃; for 2h;

With sodium tetrahydroborate; In ethanol; acetonitrile; for 0.166667h; Overall yield = 58 %; enantioselective reaction;
DOI:10.1002/ejoc.201601357