N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester

Base Information

• Chemical Name: N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester
• CAS No.: 253269-37-3
• Molecular Formula: C₁₆H₂₁N₂O₅PS
• Molecular Weight: 384.393
• Mol file: 253269-37-3.mol

Synonyms:N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester

Chemical Property of N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester

There total 5 articles about N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-cyanoethyl(phenyl)phosphinyl]-L-glutamic acid dimethyl ester (253269-39-5) → N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester (253269-37-3)

Guidance literature:

With Lawessons reagent;

DOI:10.1016/S0960-894X(99)00198-5

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) → N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester (253269-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole; diisopropylethylamine / benzene / 2 h / 4 - 20 °C

2: 0.43 g / diisopropylethylamine / benzene / 3 h / 20 °C

3: 1.12 g / Lawesson's reagent / toluene / 3 h / Heating

With Lawessons reagent; 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In toluene; benzene; 1: Condensation / 2: Condensation / 3: Substitution;

DOI:10.1021/jo991090x

Reference yield:

C9H9ClNO2P (66871-21-4) → N-[2-cyanoethyl(phenyl)phosphinothioyl]-L-glutamic acid dimethyl ester (253269-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.43 g / diisopropylethylamine / benzene / 3 h / 20 °C

2: 1.12 g / Lawesson's reagent / toluene / 3 h / Heating

With Lawessons reagent; N-ethyl-N,N-diisopropylamine; In toluene; benzene; 1: Condensation / 2: Substitution;

DOI:10.1021/jo991090x

upstream raw materials:

N-[2-cyanoethyl(phenyl)phosphinyl]-L-glutamic acid dimethyl ester

P,P-dichlorophenylphosphine oxide

C₉H₉ClNO₂P

phenylthiophosphonic acid dichloride