(S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine

Base Information

• Chemical Name: (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine
• CAS No.: 291748-22-6
• Molecular Formula: C₁₅H₂₀ClN₅S
• Molecular Weight: 337.876

Synonyms:(S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine

Chemical Property of (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine

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Technology Process of (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine

There total 6 articles about (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-amino-1-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)piperazin-1-yl]-3-phenylpropan-1-one hydrochloride → (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine (291748-22-6)

Guidance literature:

(2S)-2-amino-1-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)piperazin-1-yl]-3-phenylpropan-1-one hydrochloride; With borane; In tetrahydrofuran; for 1h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

(S)-2-Amino-1-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-3-phenyl-propan-1-one (750559-66-1) → (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine (291748-22-6)

Guidance literature:

With borane; In tetrahydrofuran;

DOI:10.1016/S0960-894X(01)00151-2

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (S)-1-Benzyl-2-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-ethylamine (291748-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: TEA; DCC; HOBt / CH₂Cl₂ / 20 °C

2: 4N aq. HCl / dioxane / 20 °C

3: BH₃ / tetrahydrofuran

With hydrogenchloride; TEA; borane; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1016/S0960-894X(01)00151-2

upstream raw materials:

(S)-2-Amino-1-[4-(4-chloro-[1,2,5]thiadiazol-3-yl)-piperazin-1-yl]-3-phenyl-propan-1-one

N-tert-butoxycarbonyl-L-phenylalanine

3-chloro-4-piperazinyl-1,2,5-thiadiazole

4-(4-chloro-[1,2,5]thiadiazol-3-yl)piperazine-1-carboxylic acid tert-butyl ester

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