D-[2-2H]GALACTOSE

Base Information

• Chemical Name: D-[2-2H]GALACTOSE
• CAS No.: 64429-86-3
• Molecular Formula: C₆H₁₂O₆
• Molecular Weight: 181.15
• Mol file: 64429-86-3.mol

Synonyms:D-[2-2H]GALACTOSE

Chemical Property of D-[2-2H]GALACTOSE

Chemical Property:

• PSA: 110.38000
• LogP: -3.22140

Purity/Quality:

99% ^*data from raw suppliers

D-Galactose-2-d ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-[2-2H]GALACTOSE is a C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis. Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis.

Technology Process of D-[2-2H]GALACTOSE

There total 3 articles about D-[2-2H]GALACTOSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl-alpha-D-glucopyranoside (97-30-3) → 2-<2H>-D-glucose (30737-83-8,64429-86-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent sodium hydride in mineral oil / 3 h / 120 °C

2: 2 M H₂SO₄ / acetic acid / 24 h / 90 °C

3: 42 percent / sodium, deuterium oxide / dioxane / 72 h / Ambient temperature

4: 1.) hydrogen, glacial acetic acid, 2.) ammonium hydroxide / 1.) palladium black / 1.) 1 atm, 24 h, 2.) methanol, 2 h

With ammonium hydroxide; sulfuric acid; hydrogen; water-d2; sodium; sodium hydride; acetic acid; palladium; In 1,4-dioxane; acetic acid;

DOI:10.1016/S0040-4020(01)88220-X

Reference yield:

2-<2H>-2,3,4,6-tetra-O-benzyl-D-glucose → 2-<2H>-D-glucose (30737-83-8,64429-86-3)

Guidance literature:

With ammonium hydroxide; hydrogen; acetic acid; palladium; Yield given. Multistep reaction; 1.) 1 atm, 24 h, 2.) methanol, 2 h;

DOI:10.1016/S0040-4020(01)88220-X

Reference yield:

→ 2-<2H>-D-glucose (30737-83-8,64429-86-3)

Guidance literature:

2-O-benzyl-D-<2-D>glucose, H2;

upstream raw materials:

methyl-alpha-D-glucopyranoside

Downstream raw materials:

L-(-)-sorbose-D₅

D-(-)-fructose-D₁

Refernces