1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

Base Information

Chemical Name:1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine
CAS No.:935248-14-9
Molecular Formula:C₂₄H₂₅ClN₄O₃
Molecular Weight:452.941
Hs Code.:

Synonyms:1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

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Chemical Property of 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

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Technology Process of 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

There total 5 articles about 1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 935248-13-8
1-{6-hydroxy-indanyl}-4-acetyl-piperazine

: 73217-30-8
3-(chloromethyl)-5-(4-chlorophenyl)-1,2,4-oxadiazole

: 935248-14-9
1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

Guidance literature:: With caesium carbonate; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 60 - 65 ℃; for 40h;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 935248-14-9
1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium borohydride / methanol / 1 h / 20 °C

2: thionyl chloride / toluene / 1.5 h / 20 - 60 °C

3: 4.6 g / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 16 h / 70 - 75 °C

4: 62 percent / BBr₃ / tetrabutylammonium iodide / CH₂Cl₂ / 14 h / 20 °C

5: 65 percent / cesium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

With sodium tetrahydroborate; thionyl chloride; boron tribromide; potassium carbonate; caesium carbonate; tetra-(n-butyl)ammonium iodide; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109

Reference yield:

: 3469-09-8
6-methoxyindan-1-ol

: 935248-14-9
1-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indanyl}-4-acetyl-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 1.5 h / 20 - 60 °C

2: 4.6 g / potassium carbonate / tetrabutylammonium iodide / acetonitrile / 16 h / 70 - 75 °C

3: 62 percent / BBr₃ / tetrabutylammonium iodide / CH₂Cl₂ / 14 h / 20 °C

4: 65 percent / cesium carbonate / tetrabutylammonium iodide / acetonitrile / 40 h / 60 - 65 °C

With thionyl chloride; boron tribromide; potassium carbonate; caesium carbonate; tetra-(n-butyl)ammonium iodide; In dichloromethane; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2006.12.109