1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate

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Chemical Name:1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate
CAS No.:934584-88-0
Molecular Formula:C₂₄H₂₈FNO₅
Molecular Weight:429.488
Hs Code.:
Mol file:934584-88-0.mol

Synonyms:(2S,5R)-1-tert-butyl 2-methyl 5-(4-(2-fluorobenzyl)oxy)phenylpyrrolidine-1,2-dicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate Edit

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate

There total 8 articles about 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

: 446-48-0
o-fluorobenzyl bromide

: 1-(tert-butyl) 2-methyl (2S,5R)-5-(4-hydroxyphenyl)pyrrolidine-1,2-dicarboxylate

: 934584-88-0
(2S,5R)-1-tert-butyl 2-methyl 5-(4-(2-fluorobenzyl)oxy)phenylpyrrolidine-1,2-dicarboxylate

Guidance literature:: With potassium carbonate; In acetone; at 25 - 35 ℃; for 30h; Inert atmosphere; Reflux;
DOI:10.1021/acs.oprd.0c00382

Reference yield:

: 934240-62-7
(2S,5R)-methyl-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxylate

: 24424-99-5
di-tert-butyl dicarbonate

: 934584-88-0
(2S,5R)-1-tert-butyl 2-methyl 5-(4-(2-fluorobenzyl)oxy)phenylpyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,5R)-methyl-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxylate; di-tert-butyl dicarbonate; In ethyl acetate; at 0 - 25 ℃; for 3h;

With malic acid; In ethyl acetate; for 0.166667h;