2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester
• CAS No.: 111222-47-0
• Molecular Formula: C₁₅H₁₈N₂O₂
• Molecular Weight: 258.32
• Mol file: 111222-47-0.mol

Synonyms:2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property of 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

There total 3 articles about 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Amino-3-ethoxycarbonyl-4-methyl-5-phenylpyrrole (111222-43-6) + dimethyl sulfate (77-78-1) → 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (111222-47-0)

Guidance literature:

With sodium hydroxide; benzyl tri-n-butylammonium bromide; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1055/s-1987-27913

Reference yield: 37.0%

2-Amino-3-ethoxycarbonyl-4-methyl-5-phenylpyrrole (111222-43-6) + dimethyl sulfate (77-78-1) → 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (111222-47-0) + 1,4-Dimethyl-2-methylamino-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (111222-48-1) + 2-Dimethylamino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (111222-49-2)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; for 4h; Product distribution; Ambient temperature; other amount of dimethyl sulfate; other catalyst;

DOI:10.1055/s-1987-27913

Reference yield:

2-bromo-1-phenyl-1-propanone (2114-00-3) → 2-Amino-1,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester (111222-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 95percent sodium ethoxide / 1.) EtOH, 10 min, 2.) 20 deg C, 24 h

2: 67 percent / 50percent aq. NaOH / benzyltributylammonium bromide / CH₂Cl₂ / 4 h / Ambient temperature

With sodium hydroxide; sodium ethanolate; benzyl tri-n-butylammonium bromide; In dichloromethane;

DOI:10.1055/s-1987-27913

upstream raw materials:

2-Amino-3-ethoxycarbonyl-4-methyl-5-phenylpyrrole

dimethyl sulfate

2-bromo-1-phenyl-1-propanone