3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine
CAS No.:118697-69-1
Molecular Formula:C₂₀H₂₀ClN₅O₂
Molecular Weight:397.864
Hs Code.:

Synonyms:3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of 3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

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Technology Process of 3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

There total 7 articles about 3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 118697-69-1
3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Et₃N / ethanol / 1.75 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 48 percent / 0.13 h / 210 - 220 °C

5: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: oxalyl chloride, DMF / 5 h / 60 °C

7: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007

Reference yield:

: 90559-63-0
N-(3-nitro-2-pyridinyl)glycine ethyl ester

: 118697-69-1
3-[2-(4-acetyl-1-piperazinyl)-2-oxoethyl]-2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 48 percent / 0.13 h / 210 - 220 °C

4: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

5: oxalyl chloride, DMF / 5 h / 60 °C

6: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007