[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

Base Information

Chemical Name:[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid
CAS No.:1207282-96-9
Molecular Formula:C₁₄H₁₂ClF₂N₃O₃
Molecular Weight:343.717
Hs Code.:

Synonyms:[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

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Technology Process of [6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

There total 1 articles about [6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1207283-04-2
[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid ethyl ester

: 1207282-96-9
[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 18h;
DOI:10.1021/jm901802n

Reference yield: 86.0%

: 226569-29-5
[N,N'-di-(tert-butoxycarbonyl)]-2-ethoxyguanidine

: 1207282-96-9
[6-chloro-3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid

: 1207283-05-3
1-{N-[2-(N',N''-bis{tert-butoxycarbonyl}aminidino-aminooxy)ethyl]amino}carbonylmethyl-6-chloro-3-[2,2-difluoro-2-phenylethylamino]pyrazinone

Guidance literature:: With benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm901802n