methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

Base Information

Chemical Name:methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate
CAS No.:123427-72-5
Molecular Formula:C₁₈H₂₅NO₅
Molecular Weight:335.4
Hs Code.:

Synonyms:methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

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Technology Process of methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

There total 12 articles about methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 123427-71-4
methyl (3S,4S)-7-iodo-1-(p-methoxyphenyl)-4-methyl-3-nitromethylheptane-4-carboxylate

: 123427-72-5
methyl (1R,2S,3S)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 14h;
DOI:10.1039/P19920001505

Reference yield: 44.0%

: 123427-83-8
methyl (3R,4S)-7-iodo-1-(p-methoxyphenyl)-4-methyl-3-nitromethylheptane-4-carboxylate

: 123427-72-5,123485-17-6,126108-62-1,143061-51-2
methyl (1R,2R)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 14h;
DOI:10.1039/P19920001505

Reference yield:

: 102631-75-4
(S)-(-)-2-Methyl-2-(2'-nitrovinyl)-δ-valerolactone

: 123427-72-5,123485-17-6,126108-62-1,143061-51-2
methyl (1R,2R)-2-<2-(p-methoxyphenyl)ethyl>-1-methyl-3-nitrocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 2 h / -78 °C

2: 100 percent / NaOMe / 8 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: NaI / acetone / 1.) room temperature, 10 h, 2.) reflux, 3 h

5: 44 percent / NaH / dimethylformamide / 14 h / 0 °C

With sodium methylate; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/P19920001505