5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

Base Information

Chemical Name:5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>
CAS No.:130328-02-8
Molecular Formula:C₃₁H₄₉BrN₄O₁₀
Molecular Weight:717.655
Hs Code.:

5-bromo-2'-deoxyuridine 3'-<N-(1,1-dimethylethoxycarbonyl)-N-<2-<N-(1,1-dimethylethoxycarbonyl)-N-(2-cyclohexylethyl)amino>ethyl>glycyl ester>

Synonyms:5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

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Chemical Property of 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

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Technology Process of 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

There total 8 articles about 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 130328-01-7
5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester>

: 130328-02-8
5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

Guidance literature:: With water; acetic acid; at 60 ℃; for 2h;
DOI:10.1021/jm00171a038

Reference yield:

: 10258-93-2
N-(2-cyclohexyl-ethyl)-ethylenediamine

: 130328-02-8
5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

Guidance literature:: Multi-step reaction with 5 steps

1: 11.1 g / H₂ / 5percent Pd/C / ethanol; H₂O / 2016.9 Torr / Ambient temperature

2: NaOH / H₂O; tetrahydrofuran / Ambient temperature

3: 59 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 20 h / Ambient temperature

4: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / 72 h / Ambient temperature

5: 61 percent / HOAc, H₂O / 2 h / 60 °C

With dmap; sodium hydroxide; water; hydrogen; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00171a038

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 130328-02-8
5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester>

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / H₂O; tetrahydrofuran / Ambient temperature

2: 59 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 20 h / Ambient temperature

3: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / 72 h / Ambient temperature

4: 61 percent / HOAc, H₂O / 2 h / 60 °C

With dmap; sodium hydroxide; water; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; acetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00171a038