(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate
CAS No.:1620056-23-6
Molecular Formula:C₁₈H₂₀BrF₂N₃O₄S
Molecular Weight:492.341
Hs Code.:

Synonyms:(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

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Technology Process of (S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

There total 1 articles about (S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620056-23-6
(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chlorosulfonic acid; at 0 - 20 ℃; for 4h;

Reference yield:

: 288-88-0
1,2,4-Triazole

: 1620056-23-6
(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

: 1620056-27-0
(S)-tert-butyl (1-(5-bromo-2-(1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1620056-23-6
(S)-tert-butyl (1-(5-bromo-2-(methylsulfonyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

: 1620056-28-1
(S)-tert-butyl (2-(3,5-difluorophenyl)-1-(5-(3-oxoisoindolin-5-yl)-2-(1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave irradiation

2: lithium chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / methanol; 1,4-dioxane; water / 0.33 h / 160 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triethylamine; lithium chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;