potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate

Base Information

• Chemical Name: potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate
• CAS No.: 1050656-08-0
• Molecular Formula: C₂₇H₁₉F₄N₂O₃*K
• Molecular Weight: 534.551
• Mol file: 1050656-08-0.mol

Synonyms:potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate

Chemical Property of potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate

There total 4 articles about potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (1050656-53-5) → potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate (1050656-08-0)

Guidance literature:

With methanol; potassium hydroxide; water;

Reference yield:

7-bromo-5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indole (1050656-45-5) → potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate (1050656-08-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.08 h / -100 °C

1.2: 0.25 h / -100 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: methanol; potassium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

3.2: pH 3

4.1: methanol; potassium hydroxide; water

With methanol; potassium hydroxide; n-butyllithium; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indole-7-carboxylic acid (1050656-47-7) → potassium 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate (1050656-08-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2.1: methanol; potassium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2.2: pH 3

3.1: methanol; potassium hydroxide; water

With methanol; potassium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid

7-bromo-5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indole

5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indole-7-carboxylic acid

7-bromo-5-fluoro-1H-indole