N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide
CAS No.:1259528-82-9
Molecular Formula:C₂₆H₂₅N₃O₆S
Molecular Weight:507.567
Hs Code.:

Synonyms:N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

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Chemical Property of N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

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Technology Process of N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

There total 12 articles about N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1259528-80-7
N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

: 73866-23-6
5-(2-bromoacetyl)-2-hydroxybenzamide

: 1259528-82-9
N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

Guidance literature:: N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

5-(2-bromoacetyl)-2-hydroxybenzamide; In N,N-dimethyl-formamide; for 8h; Inert atmosphere;

Reference yield:

: 73866-23-6
5-(2-bromoacetyl)-2-hydroxybenzamide

: 1259528-82-9
N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

Guidance literature:: With NaH; In N,N-dimethyl-formamide;

Reference yield:

: 62-53-3
aniline

: 1259528-82-9
N-(2-(3-carbamoyl-4-hydroxyphenyl)-2-oxoethyl)-N-phenyl-1-(phenylsulfonyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

1.2: 0.83 h / 0 - 20 °C

2.1: ethanol; calcium chloride; sodium tetrahydroborate / 3.67 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: potassium tert-butylate / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

5.1: dichloromethane / 1 h / 20 °C / sealed vessel

6.1: triethylamine / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

7.2: 8 h / 0 °C

With sodium tetrahydroborate; ethanol; potassium tert-butylate; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; calcium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;