1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

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Chemical Name:1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate
CAS No.:1269408-09-4
Molecular Formula:C₂₆H₃₀N₄O₃
Molecular Weight:446.549
Hs Code.:

Synonyms:1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

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Chemical Property of 1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

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Technology Process of 1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

There total 5 articles about 1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1269408-08-3
2-chloro-1-{[(phenylmethyl)oxy]methyl}-1H-indole-3-carbonitrile

: 122536-76-9,140629-77-2
3(S)-(tert-butoxycarbonylamino)pyrrolidine

: 1269408-09-4
1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 48h;

Reference yield:

: 5059-30-3
2-chloroindole-3-carboxaldehyde

: 1269408-09-4
1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; pyridine / ethanol / 1 h / Reflux

2.1: 1 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1 h

4.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C

With pyridine; hydroxylamine hydrochloride; sodium hydride; potassium carbonate; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 68096-00-4
2-chloro-1H-indole-3-carboxaldehyde oxime

: 1269408-09-4
1,1-dimethylethyl [(3S)-1-(3-cyano-1-{[(phenylmethyl)oxy]methyl}-1H-indol-2-yl)-3-pyrrolidinyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 1 h

3.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C

With sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;