N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

Base Information

Chemical Name:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide
CAS No.:911067-10-2
Molecular Formula:C₂₀H₂₇ClN₂O₃S
Molecular Weight:410.965
Hs Code.:

Synonyms:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

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Technology Process of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

There total 3 articles about N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911067-23-7
{(1S,2R)-1-Benzyl-3-[(4-chloro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

: 911067-10-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.05.063

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 911067-10-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: propan-2-ol / 2 h / 80 °C

2: triethylamine / CH₂Cl₂ / 20 °C

3: trifluoroacetic acid / CH₂Cl₂ / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2006.05.063

Reference yield:

: 160232-08-6
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

: 911067-10-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-chloro-N-isobutylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2006.05.063