N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide

Base Information

• Chemical Name: N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide
• CAS No.: 151474-75-8
• Molecular Formula: C₁₉H₁₉N₃O₃S
• Molecular Weight: 369.444
• Mol file: 151474-75-8.mol

Synonyms:N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide

Chemical Property of N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide

There total 5 articles about N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(5-Benzoylamino-4,7-dimethoxy-1-methyl-1H-indole-3-carbothioyl)-carbamic acid ethyl ester (151474-74-7) → N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide (151474-75-8)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1016/S0040-4039(00)79232-X

Reference yield:

N-(4-Amino-2,5-dimethoxyphenyl)benzamide (6268-05-9) → N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide (151474-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 72 percent / NaOMe, NaBH₄ / methanol; tetrahydrofuran

2: 26 percent / K₂CO₃ / 2-methoxy-ethanol

3: 42 percent / ZnCl₂ / dimethylformamide

4: 54 percent / toluene

5: 71 percent / KOH / ethanol

With potassium hydroxide; sodium tetrahydroborate; sodium methylate; potassium carbonate; zinc(II) chloride; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)79232-X

Reference yield:

N-(2,5-Dimethoxy-4-methylamino-phenyl)-benzamide (151474-71-4) → N-(4,7-Dimethoxy-1-methyl-3-thiocarbamoyl-1H-indol-5-yl)-benzamide (151474-75-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 26 percent / K₂CO₃ / 2-methoxy-ethanol

2: 42 percent / ZnCl₂ / dimethylformamide

3: 54 percent / toluene

4: 71 percent / KOH / ethanol

With potassium hydroxide; potassium carbonate; zinc(II) chloride; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(00)79232-X

upstream raw materials:

(5-Benzoylamino-4,7-dimethoxy-1-methyl-1H-indole-3-carbothioyl)-carbamic acid ethyl ester

N-(4-Amino-2,5-dimethoxyphenyl)benzamide

N-(2,5-Dimethoxy-4-methylamino-phenyl)-benzamide

N-(4,7-Dimethoxy-1-methyl-1H-indol-5-yl)-benzamide

Downstream raw materials:

2-(5-Benzoylamino-1-methyl-4,7-dioxo-4,7-dihydro-1H-indol-3-yl)-thiazole-4-carboxylic acid amide

2-(5-Benzoylamino-4,7-dimethoxy-1-methyl-1H-indol-3-yl)-thiazole-4-carboxylic acid amide