5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

Base Information

Chemical Name:5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester
CAS No.:1312697-71-4
Molecular Formula:C₂₁H₁₂F₉N₃O₃
Molecular Weight:525.33
Hs Code.:

Synonyms:5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

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Chemical Property of 5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

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Technology Process of 5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

There total 10 articles about 5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-20-0
2-chloroethanal

: 1312697-70-3
2-amino-6-[5-(3,5-bistrifluoromethyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-nicotinic acid methyl ester

: 1312697-71-4
5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

Guidance literature:: In isopropyl alcohol; at 50 ℃;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1312697-71-4
5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h

2.1: dichloromethane; N,N-dimethyl-formamide / 20 °C

3.1: ammonium hydroxide / 1,4-dioxane / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / xylene / 1.5 h / 130 °C

5.1: dmap / dichloromethane / 40 °C

6.1: ozone / dichloromethane; methanol / 0.42 h / -78 °C

7.1: hydroxylamine / water

8.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 40 °C

8.2: 20 °C

9.1: trifluoroacetic acid / dichloromethane; water / 20 °C

10.1: isopropyl alcohol / 50 °C

With ammonium hydroxide; N-chloro-succinimide; oxalyl dichloride; hydroxylamine; ozone; trifluoroacetic acid; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; xylene;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 1312697-71-4
5-[5-(3,5-bistrifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide / 1,4-dioxane / 0.33 h / 100 °C / Sealed tube; Microwave irradiation

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / xylene / 1.5 h / 130 °C

3.1: dmap / dichloromethane / 40 °C

4.1: ozone / dichloromethane; methanol / 0.42 h / -78 °C

5.1: hydroxylamine / water

6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 40 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane; water / 20 °C

8.1: isopropyl alcohol / 50 °C

With ammonium hydroxide; N-chloro-succinimide; hydroxylamine; ozone; trifluoroacetic acid; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; xylene;