ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

Base Information

Chemical Name:ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate
CAS No.:138129-15-4
Molecular Formula:C₂₀H₁₉N₃O₄
Molecular Weight:365.389
Hs Code.:

Synonyms:ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

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Chemical Property of ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

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Technology Process of ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

There total 4 articles about ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157097-06-8
4-Oxo-1,3(4H)-phthalazinediacetic acid

: 543-27-1
isobutyl chloroformate

: 138129-15-4
ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

Guidance literature:: With triethylamine; aniline; In chloroform;

Reference yield:

: 4-Oxo-1,3(4H)-phthalazinediacetic acid 3-(1,1-dimethyl-ethyl) 1-ethyl ester

: 138129-15-4
ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / concd. H₂SO₄ / 1 h

2: 1.) triethylamine / 1.) CHCl₃, 0 deg C, 30 min, 2.) CHCl₃, from 0 deg C to RT

With sulfuric acid; triethylamine;
DOI:10.1021/jm00081a006

Reference yield:

: 25947-13-1
ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate

: 138129-15-4
ethyl 3-<2-(phenylamino)-2-oxoethyl>-3,4-dihydro-4-oxo-1-phthalazineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) DMF, RT, 30 min, 2.) DMF, 1 h

2: 68 percent / concd. H₂SO₄ / 1 h

3: 1.) triethylamine / 1.) CHCl₃, 0 deg C, 30 min, 2.) CHCl₃, from 0 deg C to RT

With sulfuric acid; potassium tert-butylate; triethylamine;
DOI:10.1021/jm00081a006