2-Amino-5-bromobenzamide

Base Information

• Chemical Name: 2-Amino-5-bromobenzamide
• CAS No.: 16313-66-9
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.049
• Hs Code.: 29242990
• European Community (EC) Number: 845-871-5
• DSSTox Substance ID: DTXSID40407579
• Nikkaji Number: J2.484.274F
• Wikidata: Q72438370
• Mol file: 16313-66-9.mol

Synonyms:2-amino-5-bromobenzamide;16313-66-9;Benzamide, 2-amino-5-bromo-;2-amino-5-bromo-benzamide;MFCD04037881;Benzamide,2-amino-5-bromo-;5-bromanthranilamide;5-bromoanthranilamide;6-Iodo-2-picoline;SCHEMBL147774;DTXSID40407579;LHAJKJQNMKXZSZ-UHFFFAOYSA-N;AKOS015854785;CS-W008987;GS-3523;MB03086;SY062852;BB 0253301;FT-0677007;EN300-41735;O10652;Z424995924

Chemical Property of 2-Amino-5-bromobenzamide

Chemical Property:

• Appearance/Colour: Pale yellow solid
• Vapor Pressure: 0.00198mmHg at 25°C
• Melting Point: 189-191℃ (water ethanol )
• Refractive Index: 1.666
• Boiling Point: 291.2 °C at 760 mmHg
• PKA: 15.15±0.50(Predicted)
• Flash Point: 129.9 °C
• PSA: 69.11000
• Density: 1.698 g/cm³
• LogP: 2.41170
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 213.97418
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)C(=O)N)N

Technology Process of 2-Amino-5-bromobenzamide

There total 16 articles about 2-Amino-5-bromobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

anthranilic acid amide (28144-70-9,88-68-6) → 5-bromoanthranilamide (16313-66-9)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2015.11.014

Reference yield: 93.0%

(2-amino-5-bromophenyl) (benzotriazole-1-yl)methanone (1397833-71-4) → 5-bromoanthranilamide (16313-66-9)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;

DOI:10.3998/ark.5550190.0013.818

Reference yield: 90.0%

2-amino-5-bromobenzonitrile (39263-32-6) → 5-bromoanthranilamide (16313-66-9)

Guidance literature:

With Acetaldehyde oxime; nickel(II) chloride hexahydrate; water; for 10h; chemoselective reaction; Reflux;

DOI:10.1002/aoc.2876

upstream raw materials:

5-bromoisatoic anhydride

ammonia

5-Bromo-2-aminobenzoic acid

anthranilic acid amide

Downstream raw materials:

6-bromo-2-(2,4,6-trimethyl-phenyl)-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one

6-bromo-2-p-tolyl-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one

2-azido-5'-bromo-2'-carboxamidobenzanilide

2-azido-5,5'-dibromo-2'-carboxamidobenzanilide