(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Base Information

Chemical Name:(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide
CAS No.:369377-98-0
Molecular Formula:C₁₆H₁₈Cl₂N₂O₄S
Molecular Weight:405.302
Hs Code.:

Synonyms:(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Suppliers and Price of (S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

There total 8 articles about (S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 369377-96-8
(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2-hydroxy-3-(tetrahydropyran-2-yloxy)propyl]-3,N-dimethylbenzenesulfonamide

: 369377-98-0
(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 0.75h;
DOI:10.1271/bbb.65.1482

Reference yield:

: 118775-50-1
2-chloro-6-(1-chloromethylvinyl)pyridine

: 369377-98-0
(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 35.5 g / HOAc / 24 h / 100 °C

2: 90 percent / Et₃N; H₂O / methanol / 3 h / Heating

3: L-(+)-diethyl tartrate; t-butyl hydroperoxide

4: 73 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 1.5 h / 20 °C

5: 73 percent / tetra-N-butylammonium bromide; aq. NaOH / toluene / 3.5 h / 100 °C

6: 76 percent / p-toluenesulfonic acid / methanol / 0.75 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; diethyl (2R,3R)-tartrate; tetrabutylammomium bromide; water; toluene-4-sulfonic acid; acetic acid; triethylamine; In methanol; dichloromethane; toluene; 3: Sharpless-Katsuki asymmetric epoxidation;
DOI:10.1271/bbb.65.1482

Reference yield:

: 369377-89-9
2-(6-chloropyridin-2-yl)prop-2-en-1-ol

: 369377-98-0
(S)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-(+)-diethyl tartrate; t-butyl hydroperoxide

2: 73 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 1.5 h / 20 °C

3: 73 percent / tetra-N-butylammonium bromide; aq. NaOH / toluene / 3.5 h / 100 °C

4: 76 percent / p-toluenesulfonic acid / methanol / 0.75 h / 20 °C

With tert.-butylhydroperoxide; sodium hydroxide; diethyl (2R,3R)-tartrate; tetrabutylammomium bromide; toluene-4-sulfonic acid; In methanol; dichloromethane; toluene; 1: Sharpless-Katsuki asymmetric epoxidation;
DOI:10.1271/bbb.65.1482