5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

Base Information

Chemical Name:5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide
CAS No.:1025873-47-5
Molecular Formula:C₁₈H₁₃F₆N₇OS
Molecular Weight:489.404
Hs Code.:

Synonyms:5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

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Chemical Property of 5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

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Technology Process of 5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

There total 6 articles about 5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 159886-35-8
2-[4-(3-Bromopropylcarbamoyl)-5-(trifluoromethyl)pyrazol-1-yl]-4-(3-trifluoromethylphenyl)thiazole

: 1025873-47-5
5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 90 ℃; for 2h;
DOI:10.1021/jm00001a008

Reference yield:

: 1048670-08-1
2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester

: 1025873-47-5
5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) EtOH, RT, 1 h, 2.) EtOH, refux, 3 h

2: 96 percent / KOH / ethanol / 3 h / Heating

3: 1.) carbonyldiimidazole / 1.) DMF, RT, 30 min, 2.) DMF, 2 h

4: 100 percent / sodium azide / dimethylformamide / 2 h / 90 °C

With potassium hydroxide; sodium azide; 1,1'-carbonyldiimidazole; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00001a008

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 1025873-47-5
5-Trifluoromethyl-1-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-1H-pyrazole-4-carboxylic acid (3-azido-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Br₂ / diethyl ether / 3 h / Ambient temperature

2: 1.) EtOH, RT, 1 h, 2.) EtOH, refux, 3 h

3: 96 percent / KOH / ethanol / 3 h / Heating

4: 1.) carbonyldiimidazole / 1.) DMF, RT, 30 min, 2.) DMF, 2 h

5: 100 percent / sodium azide / dimethylformamide / 2 h / 90 °C

With potassium hydroxide; sodium azide; bromine; 1,1'-carbonyldiimidazole; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00001a008