4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

Base Information

Chemical Name:4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride
CAS No.:1032451-73-2
Molecular Formula:C₉H₁₈N₂O*ClH
Molecular Weight:206.716
Hs Code.:

Synonyms:4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

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Chemical Property of 4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

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Technology Process of 4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

There total 3 articles about 4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032451-72-1
(4-dimethylcarbamoyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1032451-73-2
4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 5h;

Reference yield:

: 53292-90-3,130309-46-5,53292-89-0
trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

: 1032451-73-2
4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

1.2: 64 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 5 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 146307-51-9
methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate

: 1032451-73-2
4-amino-cyclohexanecarboxylic acid dimethylamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium hydroxide / 4 h / 23 °C

2: methanol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 23 °C

3: hydrogenchloride / 1,4-dioxane / 60 °C

With hydrogenchloride; methanol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2019.115193