[3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

Base Information

• Chemical Name: [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester
• CAS No.: 945399-12-2
• Molecular Formula: C₁₉H₂₅N₃O₄
• Molecular Weight: 359.425

Synonyms:[3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

Chemical Property of [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

Chemical Property:

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Technology Process of [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

There total 1 articles about [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(4-oxopiperidin-1-yl)phenyl]acetic acid tert-butyl ester (945399-11-1) + sodium cyanide (143-33-9,25596-52-5) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester (945399-12-2)

Guidance literature:

With water; In ethanol; at 85 ℃; for 12h; Sealed tube;

Reference yield:

[3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester (945399-12-2) + cyclopropylcarbinyl bromide (7051-34-5) → [3-(3-cyclopropylmethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester (945399-19-9)

Guidance literature:

With cesium bicarbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

(Bromomethyl)cyclobutane (17247-58-4) + [3-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester (945399-12-2) → [3-(3-cyclobutylmethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester (945399-21-3)

Guidance literature:

With cesium bicarbonate; In N,N-dimethyl-formamide; at 130 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

[3-(4-oxopiperidin-1-yl)phenyl]acetic acid tert-butyl ester

sodium cyanide

ammonium carbonate

Downstream raw materials:

[3-(3-cyclopropylmethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

[3-(3-cyclobutylmethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)phenyl]acetic acid tert-butyl ester

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