(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

Base Information

Chemical Name:(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate
CAS No.:1268826-98-7
Molecular Formula:C₂₀H₃₀F₂O₃Si
Molecular Weight:384.539
Hs Code.:

Synonyms:(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

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Chemical Property of (Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

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Technology Process of (Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

There total 4 articles about (Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1268826-82-9
4-(tert-butyldimethylsilyloxy)-3,3-difluoro-4-phenylbutan-2-one

: 1268826-98-7
(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 1h;

4-(tert-butyldimethylsilyloxy)-3,3-difluoro-4-phenylbutan-2-one; In 1,2-dimethoxyethane; at 0 - 20 ℃; for 13h;
DOI:10.1021/ol103097s

Reference yield: 35.0%

: 1268826-82-9
4-(tert-butyldimethylsilyloxy)-3,3-difluoro-4-phenylbutan-2-one

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1268826-98-7
(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

Guidance literature:: In toluene; for 24h; Reflux;
DOI:10.1021/ol103097s

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1268826-98-7
(Z)-ethyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-phenylpent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / 1,2-dimethoxyethane / 1 h / 0 °C

2.2: 13 h / 0 - 20 °C

With 2,6-dimethylpyridine; sodium hydride; In 1,2-dimethoxyethane; dichloromethane; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol103097s