(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

Base Information

Chemical Name:(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene
CAS No.:92264-23-8
Molecular Formula:C₃₁H₃₁NO₃
Molecular Weight:465.592
Hs Code.:

Synonyms:(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

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Chemical Property of (2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

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Technology Process of (2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

There total 8 articles about (2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 92264-19-2
(1S,3R)-2-Benzyl-8-(1-bromo-4,5-dimethoxy-naphthalen-2-ylmethoxy)-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinoline

: 92264-23-8
(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

Guidance literature:: With triethylamine; In cyclohexane; Irradiation;
DOI:10.1016/S0040-4039(01)81225-9

Reference yield:

: 82958-26-7
8-Methoxy-1,3-dimethyl-isoquinoline; hydrobromide

: 92264-23-8
(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / hydrogen, HClO₄ / PtO₂ / methanol

2: 85 percent / K₂CO₃ / propan-1-ol

3: 94 percent / aq. HBr / Heating

4: 93 percent / C₆H₅CH₂N(n-C₄H₉)3⁽¹⁺⁾, 1N NaOH / CH₂Cl₂

5: 15 percent / N(C₂H₅)3 / cyclohexane / Irradiation

With sodium hydroxide; perchloric acid; hydrogen; benzyltri-n-butylammonium cation; potassium carbonate; triethylamine; platinum(IV) oxide; In methanol; propan-1-ol; dichloromethane; cyclohexane; hydrogen bromide;
DOI:10.1016/S0040-4039(01)81225-9

Reference yield:

: 22273-57-0
4,5-dimethoxy-2-methyl-naphthalene

: 92264-23-8
(2R,4S)-3-Benzyl-8,9-dimethoxy-2,4-dimethyl-1,3,4,6-tetrahydro-2H-5-oxa-3-aza-benzo[c]chrysene

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NBS, AIBN / cyclohexane / Heating

2: 93 percent / C₆H₅CH₂N(n-C₄H₉)3⁽¹⁺⁾, 1N NaOH / CH₂Cl₂

3: 15 percent / N(C₂H₅)3 / cyclohexane / Irradiation

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzyltri-n-butylammonium cation; triethylamine; In dichloromethane; cyclohexane;
DOI:10.1016/S0040-4039(01)81225-9