(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Base Information

Chemical Name:(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione
CAS No.:1311136-69-2
Molecular Formula:C₁₆H₁₂ClFN₂O₃
Molecular Weight:334.734
Hs Code.:

Synonyms:(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Suppliers and Price of (5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Chemical Property:

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Technology Process of (5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

There total 4 articles about (5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 338-69-2,25191-17-7,18875-37-1
D-Alanine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1311137-77-5
4-[(3-chloro-5-fluorophenyl)oxy]aniline

: 1311136-69-2
(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: bis(trichloromethyl) carbonate; 4-[(3-chloro-5-fluorophenyl)oxy]aniline; With triethylamine; In toluene; at 20 ℃; for 3h;

D-Alanine; In water; N,N-dimethyl-formamide; toluene; at 20 ℃;

With hydrogenchloride; In water; at 100 ℃; for 2h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1311136-69-2
(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 4 h / Reflux

2.1: water; ammonium chloride / iron / tetrahydrofuran / 4 h / Reflux

3.1: triethylamine / toluene / 3 h / 20 °C

3.2: 20 °C

3.3: 2 h / 100 °C

With water; potassium carbonate; ammonium chloride; triethylamine; iron; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 202982-70-5
3-chloro-5-fluoro-phenol

: 1311136-69-2
(5R)-3-{4-[(3-chloro-5-fluorophenyl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 4 h / Reflux

2.1: water; ammonium chloride / iron / tetrahydrofuran / 4 h / Reflux

3.1: triethylamine / toluene / 3 h / 20 °C

3.2: 20 °C

3.3: 2 h / 100 °C

With water; potassium carbonate; ammonium chloride; triethylamine; iron; In tetrahydrofuran; toluene; acetonitrile;