methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

Base Information

Chemical Name:methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate
CAS No.:1551577-66-2
Molecular Formula:C₂₀H₂₀Cl₂FNO₃
Molecular Weight:412.288
Hs Code.:

Synonyms:methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

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Chemical Property of methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

Chemical Property:

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Technology Process of methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

There total 6 articles about methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1551577-08-2
3-(2,4-dichlorophenyl)-5-methoxy-5-oxopentanoic acid

: 1583-88-6
4-fluoro-2-phenethylamine

: 1551577-66-2
methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: C₁₃H₉Cl₂F₃O₅

: 1551577-66-2
methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 0 - 20 °C

2: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: 74299-82-4
dimethyl 2-(2,4-dichlorobenzylidene)malonate

: 1551577-66-2
methyl 3-(2,4-dichlorophenyl)-5-((4-fluorophenethyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 1 h / 20 °C

2: hydrogenchloride; water / Reflux

3: chloroform / 0 - 20 °C

4: triethylamine / 0 - 20 °C

5: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; chloroform; 1: |Michael Addition;
DOI:10.1016/j.bmc.2013.11.053