(3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol

Base Information

• Chemical Name: (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol
• CAS No.: 688797-30-0
• Molecular Formula: C₂₂H₂₈O₂SSi
• Molecular Weight: 384.615

Synonyms:(3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol

Chemical Property of (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol

There total 9 articles about (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzoic acid (3S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-methylene-tetrahydro-thiophen-3-yl ester → (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol (688797-30-0)

Guidance literature:

With methanol; ammonia; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo035735b

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol (688797-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide

2: PPh₃; DEAD / tetrahydrofuran

3: NH₃ / methanol

With 1H-imidazole; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1081/NCN-200060072

Reference yield:

(3R,5R)-5-(hydroxymethyl)-4-methylenetetrahydrothiophen-3-ol (688797-27-5) → (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol (688797-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / imidazole / dimethylformamide

2: PPh₃; DEAD / tetrahydrofuran

3: NH₃ / methanol

With 1H-imidazole; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1081/NCN-200060072

upstream raw materials:

tert-butylchlorodiphenylsilane

(3R,5R)-5-(hydroxymethyl)-4-methylenetetrahydrothiophen-3-ol

(2R,4R)-4-benzyloxy-2-(benzyloxymethyl)-3-methylenetetrahydrothiophene

(2R,4S)-2,5-bis(benzyloxy)-3-methylenepentane-1,4-diol

Downstream raw materials:

3-Benzoyl-1-((3R,5R)-5-hydroxymethyl-4-methylene-tetrahydro-thiophen-3-yl)-5-methyl-1H-pyrimidine-2,4-dione

3-benzoyl-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-methylene-tetrahydro-thiophen-3-yl]-5-methyl-1H-pyrimidine-2,4-dione

3-Benzoyl-1-((3R,5R)-5-hydroxymethyl-4-methylene-tetrahydro-thiophen-3-yl)-1H-pyrimidine-2,4-dione

9-[(3R,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-yl]-6-chloro-9H-purine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 688797-30-0 (3S,5R)-5-[(tert-butyldiphenylsilyloxy)methyl]-4-methylenetetrahydrothiophen-3-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send