1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

Base Information

Chemical Name:1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole
CAS No.:1263474-57-2
Molecular Formula:C₁₉H₂₉N₃O₃Si
Molecular Weight:375.543
Hs Code.:

Synonyms:1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

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Chemical Property of 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

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Technology Process of 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

There total 3 articles about 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232892-80-6,1273550-48-3
5-methyl-3-(4-methyl-3-nitro-phenyl)-1H-pyrazole

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1232892-89-5
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-3-(4-methyl-3-nitro-phenyl)-1H-pyrazole

: 1263474-57-2
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

Guidance literature:: With caesium carbonate; sodium iodide; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1232892-80-6,1273550-48-3
5-methyl-3-(4-methyl-3-nitro-phenyl)-1H-pyrazole

: 76358-45-7
tert-butyldimethylsilyl chloride

: 1232892-89-5
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-3-(4-methyl-3-nitro-phenyl)-1H-pyrazole

: 1263474-57-2
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

Guidance literature:: With caesium carbonate; sodium iodide; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h; Irradiation with microwave;

Reference yield:

: 5333-27-7
1-(4-methyl-3-nitro-phenyl)-ethanone

: 1232892-89-5
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-3-(4-methyl-3-nitro-phenyl)-1H-pyrazole

: 1263474-57-2
1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-methyl-5-(4-methyl-3-nitro-phenyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 3 h / 90 °C

1.2: 16 h / 0 - 20 °C

2.1: sodium iodide; caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 100 °C / Microwave irradiation

With caesium carbonate; sodium iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;