2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one

Base Information

• Chemical Name: 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one
• CAS No.: 157131-42-5
• Molecular Formula: C₂₃H₂₂FNO₃
• Molecular Weight: 379.431
• Mol file: 157131-42-5.mol

Synonyms:2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one

Chemical Property of 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one

There total 5 articles about 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + 1-oxo-2-indanylacetyl chloride (176639-51-3) → 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one (157131-42-5)

Guidance literature:

In toluene; a) RT, 1 h, b) reflux, 24 h;

Reference yield: 80.0%

(4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + (1-oxo-2-indanyl)acetic acid (7103-80-2) → 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one (157131-42-5)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; at 0 - 20 ℃; for 17h;

Reference yield:

inden-1-one (83-33-0) → 2-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-2-oxo-ethyl}-indan-1-one (157131-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / 0.75 h / 160 °C

2: 66 percent / Zn, AcOH

3: 80 percent / N-hydroxybenzotriazole, N,N-dicyclohexylcarbodiimide / 17 h / 0 - 20 °C

With benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc;

upstream raw materials:

(4-fluorophenyl)-piperidin-4-ylmethanone

(1-oxo-2-indanyl)acetic acid

1-oxo-2-indanylacetyl chloride

inden-1-one

Downstream raw materials:

C₂₇H₃₀FNO₅