3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

Base Information

Chemical Name:3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt
CAS No.:1433405-84-5
Molecular Formula:C₁₉H₂₀ClFN₃O₃*Li
Molecular Weight:399.779
Hs Code.:

Synonyms:3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

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Chemical Property of 3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

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Technology Process of 3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

There total 10 articles about 3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₀ClFN₄O₄S

: 1433405-84-5
3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; for 4h;

Reference yield:

: 1433403-05-4
{(R)-1-[4-chloro-3-(6-chloropyridine-3-carbonyl)-2-fluorophenyl]propyl}carbamic acid tert-butyl ester

: 1433405-84-5
3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide / 50 °C

2.1: trifluoroacetic acid / dichloromethane / 20 - 70 °C

3.1: sodium hydroxide / dichloromethane; water / pH 12

3.2: 72 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 4 h

With water; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433405-84-5
3-{(R)-1-[3-(6-aminopyridine-3-carbonyl)-4-chloro-2-fluorophenyl]propylamino}butyric acid, lithium salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 0.5 h

2.1: dimethyl sulfoxide / 50 °C

3.1: trifluoroacetic acid / dichloromethane / 20 - 70 °C

4.1: sodium hydroxide / dichloromethane; water / pH 12

4.2: 72 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 4 h

With n-butyllithium; water; trifluoroacetic acid; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide;