1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

Base Information

Chemical Name:1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one
CAS No.:1542131-23-6
Molecular Formula:C₂₀H₁₉N₃O₃S
Molecular Weight:381.455
Hs Code.:

Synonyms:1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

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Chemical Property of 1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

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Technology Process of 1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

There total 5 articles about 1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1542131-22-5
4-methoxy-1-methylpyridinium trifluoromethanesulfonate

: 15728-44-6
1-(4-methyl-benzenesulfonyl)-benzimidazole

: 1542131-23-6
1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: 1-(4-methyl-benzenesulfonyl)-benzimidazole; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -20 - -10 ℃; for 0.166667h; Inert atmosphere;

4-methoxy-1-methylpyridinium trifluoromethanesulfonate; In tetrahydrofuran; n-heptane; ethylbenzene; at -20 - -10 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/ol403630g

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 1542131-23-6
1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethyl acetate / 4 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.17 h / -20 - -10 °C / Inert atmosphere

2.2: 0.17 h / -20 - -10 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; ethyl acetate;
DOI:10.1021/ol403630g

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1542131-23-6
1-methyl-2-(1-tosyl-1H-benzo[d]imidazol-2-yl)-2,3-dihydropyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / ethyl acetate / 4 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.17 h / -20 - -10 °C / Inert atmosphere

2.2: 0.17 h / -20 - -10 °C / Inert atmosphere

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; ethyl acetate;
DOI:10.1021/ol403630g