2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

Base Information

Chemical Name:2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide
CAS No.:727375-10-2
Molecular Formula:C₂₁H₂₄F₄N₂O₃
Molecular Weight:428.427
Hs Code.:

Synonyms:2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

Chemical Property:

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Technology Process of 2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

There total 4 articles about 2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 271587-47-4
2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane

: 28144-70-9,88-68-6
anthranilic acid amide

: 727375-10-2
2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

Guidance literature:: In N,N-dimethyl-formamide; at 140 ℃; for 20h;
DOI:10.1021/jm061273t

Reference yield:

: 609806-82-8
1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

: 727375-10-2
2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylsulfoxide / 0.5 h

1.2: dimethylsulfoxide / 2 h

2.1: 447 mg / dimethylformamide / 20 h / 140 °C

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm061273t

Reference yield:

: 400-31-7
1,1,1-trifluoro-4-methyl-pent-3-en-2-one

: 727375-10-2
2-[[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 20.3 g / CuI / diethyl ether; tetrahydrofuran / 0 - 20 °C

2.1: NaH / dimethylsulfoxide / 0.5 h

2.2: dimethylsulfoxide / 2 h

3.1: 447 mg / dimethylformamide / 20 h / 140 °C

With copper(l) iodide; sodium hydride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm061273t