1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

Base Information

Chemical Name:1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate
CAS No.:1354722-07-8
Molecular Formula:C₂₃H₃₄BrN₃O₄Si
Molecular Weight:524.53
Hs Code.:

Synonyms:1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

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Chemical Property of 1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

Chemical Property:

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Technology Process of 1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

There total 6 articles about 1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₂BrN₃O₂Si

: 1354722-07-8
1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

Guidance literature:: In hexane; dichloromethane; at 0 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ol203463n

Reference yield:

: 1039045-55-0
3-azido-1-(2-bromophenyl)-propan-1-one

: 1354722-07-8
1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

1.2: 18 h / -78 - 25 °C / Inert atmosphere

2.1: hexane; dichloromethane / 18 h / 0 °C / Inert atmosphere

With n-butyllithium; In hexane; dichloromethane;
DOI:10.1021/ol203463n

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1354722-07-8
1-azido-3-(2-bromophenyl)-6-(triisopropylsilyloxy)hex-4-yn-3-yl methyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / Inert atmosphere

2.1: Inert atmosphere

3.1: sodium azide; acetic acid / water / Inert atmosphere

4.1: n-butyllithium / hexane; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

4.2: 18 h / -78 - 25 °C / Inert atmosphere

5.1: hexane; dichloromethane / 18 h / 0 °C / Inert atmosphere

With n-butyllithium; sodium azide; acetic acid; In tetrahydrofuran; hexane; dichloromethane; water; 2.1: Jones oxidation;
DOI:10.1021/ol203463n