3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

Base Information

Chemical Name:3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide
CAS No.:1079399-00-0
Molecular Formula:C₃₆H₄₃F₂N₃O₇S
Molecular Weight:699.816
Hs Code.:

3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

Synonyms:3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

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Chemical Property of 3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

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Technology Process of 3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

There total 9 articles about 3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3-allyl-5-(isopropanesulphonylmethylamino) benzoic acid

: 1079398-99-4
6-(3-allyI-5-fluorophenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid(4-fluorophenyl)amide

: 1079399-00-0
3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

Guidance literature:: 3-allyl-5-(isopropanesulphonylmethylamino) benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

6-(3-allyI-5-fluorophenoxy)-5S-amino-4S-hydoxy-2R-methoxy-hexanoic acid(4-fluorophenyl)amide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8.17h;

Reference yield:

: 29578-39-0
1-bromo-3-fluoro-5-methoxybenzene

: 1079399-00-0
3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / hydrogenchloride; iodine / diethyl ether / 1.5 h / 20 °C / Heating / reflux

1.2: 20 °C

2.1: boron tribromide / dichloromethane / 3 h / 0 °C

3.1: potassium carbonate / acetone / 20 °C

4.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 70 °C

5.1: polymer suported triphenylphosphine / tetrahydrofuran; methanol / 24 h

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

6.2: 8.17 h / 0 - 20 °C

With 2-hydroxypyridin; boron tribromide; potassium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; HATU; hydrogenchloride; iodine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1079398-67-6
5S-(1S-azido-2-hydroxyethyl)-3R-methoxydihydro furan-2-one

: 1079399-00-0
3-allyl-5-fluoro-N-[1S-(3-allylphenoxymethyl)-4R-(4-fluoro-phenylcarbamoyl)-2S-hydroxy-4R-methoxy-butyl]-5-(isopropanesulphonylmethylamino)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0.67 h / 0 °C

2.1: potassium carbonate / acetone / 20 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 70 °C

4.1: polymer suported triphenylphosphine / tetrahydrofuran; methanol / 24 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 0 °C

5.2: 8.17 h / 0 - 20 °C

With pyridine; 2-hydroxypyridin; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;